Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy

In Huntington's disease (HD), the size of the expanded HTT CAG repeat mutation is the primary driver of the processes that determine age at onset of motor symptoms. However, correlation of cellular biochemical parameters also extends across the normal repeat range, supporting the view that the...

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Main Authors: Lee, Jong-Min, Galkina, Ekaterina I., Levantovsky, Rachel M., Fossale, Elisa, Anne Anderson, Mary, Gillis, Tammy, Srinidhi Mysore, Jayalakshmi, Coser, Kathryn R., Shioda, Toshi, Zhang, Bin, Furia, Matthew D., Derry, Jonathan, Kohane, Isaac S., Seong, Ihn Sik, Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723309/
https://ncbi.nlm.nih.gov/pubmed/23595883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt176
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