Rrs1 Is Involved in Endoplasmic Reticulum Stress Response in Huntington Disease

The induction of Rrs1 expression is one of the earliest events detected in a presymptomatic knock-in mouse model of Huntington disease (HD). Rrs1 up-regulation fulfills the HD criteria of dominance, striatal specificity, and polyglutamine dependence. Here we show that mammalian Rrs1 is localized bot...

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Detalhes bibliográficos
Main Authors: Carnemolla, Alisia, Fossale, Elisa, Agostoni, Elena, Michelazzi, Silvia, Calligaris, Raffaella, De Maso, Luca, Del Sal, Giannino, MacDonald, Marcy E., Persichetti, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709382/
https://ncbi.nlm.nih.gov/pubmed/19433866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018325
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