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Calcium Handling by Endoplasmic Reticulum and Mitochondria in a Cell Model of Huntington’s Disease
Huntington disease (HD) is caused by the CAG (Q) expansion in exon 1 of the IT15 gene encoding a polyglutamine (poly-Q) stretch of the Huntingtin protein (Htt). In the wild type protein, the repeats specify a stretch of up 34 Q in the N-terminal portion of Htt. In the pathological protein (mHtt) the...
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| Publicado no: | PLoS Curr |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4720599/ https://ncbi.nlm.nih.gov/pubmed/26819834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.37fcb1c9a27503dc845594ee4a7316c3 |
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