Calcium Handling by Endoplasmic Reticulum and Mitochondria in a Cell Model of Huntington’s Disease

Huntington disease (HD) is caused by the CAG (Q) expansion in exon 1 of the IT15 gene encoding a polyglutamine (poly-Q) stretch of the Huntingtin protein (Htt). In the wild type protein, the repeats specify a stretch of up 34 Q in the N-terminal portion of Htt. In the pathological protein (mHtt) the...

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Vydáno v:PLoS Curr
Hlavní autoři: De Mario, Agnese, Scarlatti, Chiara, Costiniti, Veronica, Primerano, Simona, Lopreiato, Raffaele, Calì, Tito, Brini, Marisa, Giacomello, Marta, Carafoli, Ernesto
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720599/
https://ncbi.nlm.nih.gov/pubmed/26819834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.37fcb1c9a27503dc845594ee4a7316c3
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