PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder characterized by a polyglutamine expansion within the N-terminal region of huntingtin protein (HTT). Cellular mechanisms promoting mutant huntingtin (mHTT) clearance are of great interest in HD pathology as they can...

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Dades bibliogràfiques
Publicat a:Front Cell Neurosci
Autors principals: Carnemolla, Alisia, Michelazzi, Silvia, Agostoni, Elena
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420564/
https://ncbi.nlm.nih.gov/pubmed/28533744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00121
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