Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation

Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines in the first exon of huntingtin (HTT), which confers aggregation-promoting properties to amino-terminal fragments of the protein (N-HTT). Mutant N-HTT aggregates are enriched for ubiquitin and contain ub...

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Bibliografiska uppgifter
Huvudupphovsmän: Zucchelli, Silvia, Marcuzzi, Federica, Codrich, Marta, Agostoni, Elena, Vilotti, Sandra, Biagioli, Marta, Pinto, Milena, Carnemolla, Alisia, Santoro, Claudio, Gustincich, Stefano, Persichetti, Francesca
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Neurobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137084/
https://ncbi.nlm.nih.gov/pubmed/21454471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187591
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