Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models

Huntington's disease (HD) is a devastating neurodegenerative disorder with no disease-modifying treatments available. The disease is caused by expansion of a CAG trinucleotide repeat and manifests with progressive motor abnormalities, psychiatric symptoms, and cognitive decline. Expression of a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sontag, Emily Mitchell, Lotz, Gregor P., Agrawal, Namita, Tran, Andrew, Aron, Rebecca, Yang, Guocheng, Necula, Mihaela, Lau, Alice, Finkbeiner, Steven, Glabe, Charles, Marsh, J. Lawrence, Muchowski, Paul J., Thompson, Leslie M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2012
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546821/
https://ncbi.nlm.nih.gov/pubmed/22875942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0895-12.2012
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