Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases

Por van der Putten, Herman, Lotz, Gregor P.
Publicado em 2013

Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING

Por Bidinosti, Michael, Shimshek, Derya R., Mollenhauer, Brit, Marcellin, David, Schweizer, Tatjana, Lotz, Gregor P., Schlossmacher, Michael G., Weiss, Andreas
Publicado em 2012

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo

Por Legleiter, Justin, Mitchell, Emily, Lotz, Gregor P., Sapp, Ellen, Ng, Cheping, DiFiglia, Marian, Thompson, Leslie M., Muchowski, Paul J.
Publicado em 2010

Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment

Por Legleiter, Justin, Lotz, Gregor P., Miller, Jason, Ko, Jan, Ng, Cheping, Williams, Geneva L., Finkbeiner, Steve, Patterson, Paul H., Muchowski, Paul J.
Publicado em 2009

Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

Por Lotz, Gregor P., Legleiter, Justin, Aron, Rebecca, Mitchell, Emily J., Huang, Shao-Yi, Ng, Cheping, Glabe, Charles, Thompson, Leslie M., Muchowski, Paul J.
Publicado em 2010

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules

Por Sontag, Emily Mitchell, Lotz, Gregor P., Yang, Guocheng, Sontag, Christopher J., Cummings, Brian J., Glabe, Charles G., Muchowski, Paul J., Thompson, Leslie Michels
Publicado em 2012

Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington’s disease

Por Chen, Xuesong, Wu, Jun, Luo, Yuan, Liang, Xia, Supnet, Charlene, Kim, Mee Whi, Lotz, Gregor P., Yang, Guocheng, Muchowski, Paul J., Kodadek, Thomas, Bezprozvanny, Ilya
Publicado em 2011

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

Por Wacker, Jennifer L., Huang, Shao-Yi, Steele, Andrew D., Aron, Rebecca, Lotz, Gregor P., Nguyen, QuangVu, Giorgini, Flaviano, Roberson, Erik D., Lindquist, Susan, Masliah, Eliezer, Muchowski, Paul J.
Publicado em 2009

Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models

Por Sontag, Emily Mitchell, Lotz, Gregor P., Agrawal, Namita, Tran, Andrew, Aron, Rebecca, Yang, Guocheng, Necula, Mihaela, Lau, Alice, Finkbeiner, Steven, Glabe, Charles, Marsh, J. Lawrence, Muchowski, Paul J., Thompson, Leslie M.
Publicado em 2012

Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging

Por Marcellin, David, Abramowski, Dorothee, Young, Douglas, Richter, Jens, Weiss, Andreas, Marcel, Audrey, Maassen, Julia, Kauffmann, Muriel, Bibel, Miriam, Shimshek, Derya R., Faull, Richard L. M., Bates, Gillian P., Kuhn, Rainer R., Van der Putten, P. Herman, Schmid, Peter, Lotz, Gregor P.
Publicado em 2012

Identifying polyglutamine protein species in situ that best predict neurodegeneration

Por Miller, Jason, Arrasate, Montserrat, Brooks, Elizabeth, Peters-Libeu, Clare, Legleiter, Justin, Hatters, Danny, Curtis, Jessica, Cheung, Kenneth, Krishnan, Preethi, Mitra, Siddhartha, Widjaja, Kartika, Shaby, Benjamin A., Lotz, Gregor P., Newhouse, Yvonne, Mitchell, Emily, Osmand, Alex, Gray, Michelle, Thulasiramin, Vanitha, Saudou, Frederic, Segal, Mark, Yang, X. William, Masliah, Eliezer, Thompson, Leslie M., Muchowski, Paul J., Weisgraber, Karl H., Finkbeiner, Steven
Publicado em 2011