Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington’s disease

Polyglutamine(polyQ)-expanded proteins are potential therapeutic targets for the treatment of polyQ expansion disorders such as Huntington’s disease (HD) and spinocerebellar ataxia type 3 (SCA3). Here we used an amino-terminal fragment of a mutant Huntingtin protein (Htt-N-82Q) as bait in an unbiase...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chen, Xuesong, Wu, Jun, Luo, Yuan, Liang, Xia, Supnet, Charlene, Kim, Mee Whi, Lotz, Gregor P., Yang, Guocheng, Muchowski, Paul J., Kodadek, Thomas, Bezprozvanny, Ilya
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183433/
https://ncbi.nlm.nih.gov/pubmed/21944750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.06.010
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares