Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment

Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine (polyQ) domain in the N-terminal region of huntingtin (htt). PolyQ expansion above 35–40 results in disease associated with htt aggregation into inclusion bodies. It has been hypothesized that expanded...

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Hlavní autoři: Legleiter, Justin, Lotz, Gregor P., Miller, Jason, Ko, Jan, Ng, Cheping, Williams, Geneva L., Finkbeiner, Steve, Patterson, Paul H., Muchowski, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755888/
https://ncbi.nlm.nih.gov/pubmed/19491400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016923
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