Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

Inclusion bodies of aggregated mutant huntingtin (htt) fragments are a neuropathological hallmark of Huntington disease (HD). The molecular chaperones Hsp70 and Hsp40 colocalize to inclusion bodies and are neuroprotective in HD animal models. How these chaperones suppress mutant htt toxicity is uncl...

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Detalhes bibliográficos
Main Authors: Lotz, Gregor P., Legleiter, Justin, Aron, Rebecca, Mitchell, Emily J., Huang, Shao-Yi, Ng, Cheping, Glabe, Charles, Thompson, Leslie M., Muchowski, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992252/
https://ncbi.nlm.nih.gov/pubmed/20864533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160218
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