Identifying polyglutamine protein species in situ that best predict neurodegeneration

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function on proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies (IBs...

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Main Authors: Miller, Jason, Arrasate, Montserrat, Brooks, Elizabeth, Peters-Libeu, Clare, Legleiter, Justin, Hatters, Danny, Curtis, Jessica, Cheung, Kenneth, Krishnan, Preethi, Mitra, Siddhartha, Widjaja, Kartika, Shaby, Benjamin A., Lotz, Gregor P., Newhouse, Yvonne, Mitchell, Emily, Osmand, Alex, Gray, Michelle, Thulasiramin, Vanitha, Saudou, Frederic, Segal, Mark, Yang, X. William, Masliah, Eliezer, Thompson, Leslie M., Muchowski, Paul J., Weisgraber, Karl H., Finkbeiner, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271120/
https://ncbi.nlm.nih.gov/pubmed/22037470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.694
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