Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure

Abnormal polyglutamine (polyQ) tracts are the only common feature in nine proteins that each cause a dominant neurodegenerative disorder. In Huntington’s disease (HD), tracts longer than 36 glutamines in the protein huntingtin (htt) cause degeneration. In situ, monoclonal antibody 3B5H10 binds to di...

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Bibliografiske detaljer
Main Authors: Peters-Libeu, Clare, Miller, Jason, Rutenber, Earl, Newhouse, Yvonne, Krishnan, Preethi, Cheung, Kenneth, Hatters, Danny, Brooks, Elizabeth, Widjaja, Kartika, Tran, Tina, Mitra, Siddhartha, Arrasate, Montserrat, Mosquera, Luis A., Taylor, Dean, Weisgraber, Karl H., Finkbeiner, Steven
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358578/
https://ncbi.nlm.nih.gov/pubmed/22306738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.01.034
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