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Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure
Abnormal polyglutamine (polyQ) tracts are the only common feature in nine proteins that each cause a dominant neurodegenerative disorder. In Huntington’s disease (HD), tracts longer than 36 glutamines in the protein huntingtin (htt) cause degeneration. In situ, monoclonal antibody 3B5H10 binds to di...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358578/ https://ncbi.nlm.nih.gov/pubmed/22306738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.01.034 |
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