Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

An expanded polyglutamine (polyQ) stretch in the protein huntingtin (htt) induces self-aggregation into inclusion bodies (IBs) and causes Huntington's disease (HD). Defining precise relationships between early observable variables and neuronal death at the molecular and cellular levels should i...

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Main Authors: Miller, Jason, Arrasate, Montserrat, Shaby, Benjamin A., Mitra, Siddhartha, Masliah, Eliezer, Finkbeiner, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078518/
https://ncbi.nlm.nih.gov/pubmed/20685997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0146-10.2010
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