Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

An expanded polyglutamine (polyQ) stretch in the protein huntingtin (htt) induces self-aggregation into inclusion bodies (IBs) and causes Huntington's disease (HD). Defining precise relationships between early observable variables and neuronal death at the molecular and cellular levels should i...

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Xehetasun bibliografikoak
Egile Nagusiak: Miller, Jason, Arrasate, Montserrat, Shaby, Benjamin A., Mitra, Siddhartha, Masliah, Eliezer, Finkbeiner, Steven
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2010
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078518/
https://ncbi.nlm.nih.gov/pubmed/20685997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0146-10.2010
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