Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

An expanded polyglutamine (polyQ) stretch in the protein huntingtin (htt) induces self-aggregation into inclusion bodies (IBs) and causes Huntington's disease (HD). Defining precise relationships between early observable variables and neuronal death at the molecular and cellular levels should i...

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Autores principales: Miller, Jason, Arrasate, Montserrat, Shaby, Benjamin A., Mitra, Siddhartha, Masliah, Eliezer, Finkbeiner, Steven
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078518/
https://ncbi.nlm.nih.gov/pubmed/20685997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0146-10.2010
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