Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

An expanded polyglutamine (polyQ) stretch in the protein huntingtin (htt) induces self-aggregation into inclusion bodies (IBs) and causes Huntington's disease (HD). Defining precise relationships between early observable variables and neuronal death at the molecular and cellular levels should i...

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Hauptverfasser: Miller, Jason, Arrasate, Montserrat, Shaby, Benjamin A., Mitra, Siddhartha, Masliah, Eliezer, Finkbeiner, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078518/
https://ncbi.nlm.nih.gov/pubmed/20685997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0146-10.2010
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