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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
In polyglutamine (polyQ) diseases, only certain neurons die, despite widespread expression of the offending protein. PolyQ expansion may induce neurodegeneration by impairing proteostasis, but protein aggregation and toxicity tend to confound conventional measurements of protein stability. Here, we...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3900497/ https://ncbi.nlm.nih.gov/pubmed/23873212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1308 |
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