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Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
Selective neuronal loss is a hallmark of neurodegenerative diseases, including Huntington’s disease (HD). Although mutant huntingtin, the protein responsible for HD, is expressed ubiquitously, a subpopulation of neurons in the striatum is the first to succumb. In this review, we examine evidence tha...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4124811/ https://ncbi.nlm.nih.gov/pubmed/25147502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00218 |
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