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Dopaminergic Signaling and Striatal Neurodegeneration in Huntington's Disease
Huntington's disease (HD) is a neurodegenerative disorder caused by polyglutamine (polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Htt(exp) causes selective degeneration of striatal medium spiny neurons (MSNs) in HD patients. Striatal MSN neurons receive glutamatergic input fro...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307545/ https://ncbi.nlm.nih.gov/pubmed/17652581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1396-07.2007 |
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