Neuroprotective Effects of Inositol 1,4,5-Trisphosphate Receptor C-Terminal Fragment in a Huntington's Disease Mouse Model

Huntington's disease (HD) is a dominantly inherited, progressive neurodegenerative disease caused by an expanded polyglutamine tract in huntingtin protein (Htt). Medium spiny striatal neurons (MSNs) are primarily affected in HD. Mutant huntingtin protein (Htt(exp)) specifically binds to and act...

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Detalhes bibliográficos
Main Authors: Tang, Tie-Shan, Guo, Caixia, Wang, Hongyu, Chen, Xi, Bezprozvanny, Ilya
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768402/
https://ncbi.nlm.nih.gov/pubmed/19193873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4411-08.2009
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