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Neuroprotective Effects of Inositol 1,4,5-Trisphosphate Receptor C-Terminal Fragment in a Huntington's Disease Mouse Model

Huntington's disease (HD) is a dominantly inherited, progressive neurodegenerative disease caused by an expanded polyglutamine tract in huntingtin protein (Htt). Medium spiny striatal neurons (MSNs) are primarily affected in HD. Mutant huntingtin protein (Htt(exp)) specifically binds to and act...

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Bibliografiske detaljer
Main Authors: Tang, Tie-Shan, Guo, Caixia, Wang, Hongyu, Chen, Xi, Bezprozvanny, Ilya
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768402/
https://ncbi.nlm.nih.gov/pubmed/19193873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4411-08.2009
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