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Tetrabenazine is neuroprotective in Huntington's disease mice

BACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Httexp causes selective degeneration of striatal medium spiny neurons (MSN) in HD patients. A number of previous studies suggested th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Hongyu, Chen, Xi, Li, Yuemei, Tang, Tie-Shan, Bezprozvanny, Ilya
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873255/
https://ncbi.nlm.nih.gov/pubmed/20420689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-18
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