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Tetrabenazine is neuroprotective in Huntington's disease mice
BACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Httexp causes selective degeneration of striatal medium spiny neurons (MSN) in HD patients. A number of previous studies suggested th...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2873255/ https://ncbi.nlm.nih.gov/pubmed/20420689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-18 |
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