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Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease

The accumulation of mutant protein in intracellular aggregates is a common feature of neurodegenerative disease. In Huntington disease, mutant huntingtin leads to inclusion body (IB) formation and neuronal toxicity. Impairment of the ubiquitin-proteasome system (UPS) has been implicated in IB format...

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Detalhes bibliográficos
Main Authors: Mitra, Siddhartha, Tsvetkov, Andrey S., Finkbeiner, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640959/
https://ncbi.nlm.nih.gov/pubmed/19074152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806269200
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