The Ubiquitin-Proteasome Pathway in Huntington's Disease
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity. Accompanying neuronal death, mutant huntingtin aggregates in large macromolecular structures called inclusion...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley
2008-01-01
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| Serier: | The Scientific World Journal |
| Online adgang: | http://dx.doi.org/10.1100/tsw.2008.60 |
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