The Lysine 48 and Lysine 63 Ubiquitin Conjugates Are Processed Differently by the 26 S Proteasome

The role of Lys-63 ubiquitin chains in targeting proteins for proteasomal degradation is still obscure. We systematically compared proteasomal processing of Lys-63 ubiquitin chains with that of the canonical proteolytic signal, Lys-48 ubiquitin chains. Quantitative mass spectrometric analysis of ubi...

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Bibliographic Details
Main Authors: Jacobson, Andrew D., Zhang, Nan-Yan, Xu, Ping, Han, Ke-Jun, Noone, Seth, Peng, Junmin, Liu, Chang-Wei
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790978/
https://ncbi.nlm.nih.gov/pubmed/19858201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.052928
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