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The Ubiquitin-Proteasome Pathway in Huntington's Disease
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity. Accompanying neuronal death, mutant huntingtin aggregates in large macromolecular structures called inclu...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
TheScientificWorldJOURNAL
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2637619/ https://ncbi.nlm.nih.gov/pubmed/18454252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/tsw.2008.60 |
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