Identifying polyglutamine protein species in situ that best predict neurodegeneration

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function on proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies (IBs...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Miller, Jason, Arrasate, Montserrat, Brooks, Elizabeth, Peters-Libeu, Clare, Legleiter, Justin, Hatters, Danny, Curtis, Jessica, Cheung, Kenneth, Krishnan, Preethi, Mitra, Siddhartha, Widjaja, Kartika, Shaby, Benjamin A., Lotz, Gregor P., Newhouse, Yvonne, Mitchell, Emily, Osmand, Alex, Gray, Michelle, Thulasiramin, Vanitha, Saudou, Frederic, Segal, Mark, Yang, X. William, Masliah, Eliezer, Thompson, Leslie M., Muchowski, Paul J., Weisgraber, Karl H., Finkbeiner, Steven
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271120/
https://ncbi.nlm.nih.gov/pubmed/22037470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.694
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