Identifying polyglutamine protein species in situ that best predict neurodegeneration

Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function on proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies (IBs...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Miller, Jason, Arrasate, Montserrat, Brooks, Elizabeth, Peters-Libeu, Clare, Legleiter, Justin, Hatters, Danny, Curtis, Jessica, Cheung, Kenneth, Krishnan, Preethi, Mitra, Siddhartha, Widjaja, Kartika, Shaby, Benjamin A., Lotz, Gregor P., Newhouse, Yvonne, Mitchell, Emily, Osmand, Alex, Gray, Michelle, Thulasiramin, Vanitha, Saudou, Frederic, Segal, Mark, Yang, X. William, Masliah, Eliezer, Thompson, Leslie M., Muchowski, Paul J., Weisgraber, Karl H., Finkbeiner, Steven
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271120/
https://ncbi.nlm.nih.gov/pubmed/22037470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.694
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