Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING

Familial Parkinson disease (PD) can result from α-synuclein gene multiplication, implicating the reduction of neuronal α-synuclein as a therapeutic target. Moreover, α-synuclein content in human cerebrospinal fluid (CSF) represents a PD biomarker candidate. However, capture-based assays for α-synucl...

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Detalhes bibliográficos
Main Authors: Bidinosti, Michael, Shimshek, Derya R., Mollenhauer, Brit, Marcellin, David, Schweizer, Tatjana, Lotz, Gregor P., Schlossmacher, Michael G., Weiss, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460466/
https://ncbi.nlm.nih.gov/pubmed/22843695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.379792
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