Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin

Huntington's disease (HD), a progressive neurodegenerative disease, is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein (mHTT) with a polyglutamine-repeat expansion. Onset of symptoms in mutant huntingtin gene-carrying individuals remains unpredictable. We report t...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Tan, Z, Dai, W, van Erp, T G M, Overman, J, Demuro, A, Digman, M A, Hatami, A, Albay, R, Sontag, E M, Potkin, K T, Ling, S, Macciardi, F, Bunney, W E, Long, J D, Paulsen, J S, Ringman, J M, Parker, I, Glabe, C, Thompson, L M, Chiu, W, Potkin, S G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Immediate Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718563/
https://ncbi.nlm.nih.gov/pubmed/26100538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.81
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