Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo

BACKGROUND: Huntingtin, the HD gene encoded protein mutated by polyglutamine expansion in Huntington's disease, is required in extraembryonic tissues for proper gastrulation, implicating its activities in nutrition or patterning of the developing embryo. To test these possibilities, we have use...

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Bibliografische gegevens
Hoofdauteurs: Woda, Juliana M, Calzonetti, Teresa, Hilditch-Maguire, Paige, Duyao, Mabel P, Conlon, Ronald A, MacDonald, Marcy E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2005
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1208873/
https://ncbi.nlm.nih.gov/pubmed/16109169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-5-17
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