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Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

The effect of expressing human huntingtin fragments containing polyglutamine (polyQ) tracts of varying lengths was assessed in Caenorhabditis elegans ASH sensory neurons in young and old animals. Expression of a huntingtin fragment containing a polyQ tract of 150 residues (Htn-Q150) led to progressi...

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Auteurs principaux: Faber, Peter W., Alter, Janet R., MacDonald, Marcy E., Hart, Anne C.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC15113/
https://ncbi.nlm.nih.gov/pubmed/9874792
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