Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

Expansion of polyglutamine repeats in several unrelated proteins causes neurodegenerative diseases with distinct but related pathologies. To provide a model system for investigating common pathogenic features, we have examined the behavior of polyglutamine expansions expressed in Caenorhabditis eleg...

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Main Authors: Satyal, Sanjeev H., Schmidt, Enrico, Kitagawa, Kazunori, Sondheimer, Neal, Lindquist, Susan, Kramer, James M., Morimoto, Richard I.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18505/
https://ncbi.nlm.nih.gov/pubmed/10811890
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