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Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

The effect of expressing human huntingtin fragments containing polyglutamine (polyQ) tracts of varying lengths was assessed in Caenorhabditis elegans ASH sensory neurons in young and old animals. Expression of a huntingtin fragment containing a polyQ tract of 150 residues (Htn-Q150) led to progressi...

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Autori principali: Faber, Peter W., Alter, Janet R., MacDonald, Marcy E., Hart, Anne C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC15113/
https://ncbi.nlm.nih.gov/pubmed/9874792
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