ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

It is unclear whether mutations in fused in sarcoma (FUS) cause familial amyotrophic lateral sclerosis via a loss-of-function effect due to titrating FUS from the nucleus or a gain-of-function effect from cytoplasmic overabundance. To investigate this question, we generated a series of independent C...

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Hlavní autoři: Murakami, Tetsuro, Yang, Seung-Pil, Xie, Lin, Kawano, Taizo, Fu, Donald, Mukai, Asuka, Bohm, Christopher, Chen, Fusheng, Robertson, Janice, Suzuki, Hiroshi, Tartaglia, Gian Gaetano, Vendruscolo, Michele, Kaminski Schierle, Gabriele S., Chan, Fiona T.S., Moloney, Aileen, Crowther, Damian, Kaminski, Clemens F., Zhen, Mei, St George-Hyslop, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235006/
https://ncbi.nlm.nih.gov/pubmed/21949354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr417
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