FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the LC domain...

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Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Qamar, Seema, Wang, GuoZhen, Randle, Suzanne J., Ruggeri, Francesco Simone, Varela, Juan A., Lin, Julie Qiaojin, Phillips, Emma C., Miyashita, Akinori, Williams, Declan, Ströhl, Florian, Meadows, William, Ferry, Rodylyn, Dardov, Victoria J., Tartaglia, Gian G., Farrer, Lindsay A., Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Holt, Christine E., Fraser, Paul E., Schmitt-Ulms, Gerold, Klenerman, David, Knowles, Tuomas, Vendruscolo, Michele, St George-Hyslop, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927716/
https://ncbi.nlm.nih.gov/pubmed/29677515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.056
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