FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the LC domain...

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發表在:Cell
Main Authors: Qamar, Seema, Wang, GuoZhen, Randle, Suzanne J., Ruggeri, Francesco Simone, Varela, Juan A., Lin, Julie Qiaojin, Phillips, Emma C., Miyashita, Akinori, Williams, Declan, Ströhl, Florian, Meadows, William, Ferry, Rodylyn, Dardov, Victoria J., Tartaglia, Gian G., Farrer, Lindsay A., Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Holt, Christine E., Fraser, Paul E., Schmitt-Ulms, Gerold, Klenerman, David, Knowles, Tuomas, Vendruscolo, Michele, St George-Hyslop, Peter
格式: Artigo
語言:Inglês
出版: Cell Press 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927716/
https://ncbi.nlm.nih.gov/pubmed/29677515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.056
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