FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the LC domain...

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מידע ביבליוגרפי
הוצא לאור ב:Cell
Main Authors: Qamar, Seema, Wang, GuoZhen, Randle, Suzanne J., Ruggeri, Francesco Simone, Varela, Juan A., Lin, Julie Qiaojin, Phillips, Emma C., Miyashita, Akinori, Williams, Declan, Ströhl, Florian, Meadows, William, Ferry, Rodylyn, Dardov, Victoria J., Tartaglia, Gian G., Farrer, Lindsay A., Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Holt, Christine E., Fraser, Paul E., Schmitt-Ulms, Gerold, Klenerman, David, Knowles, Tuomas, Vendruscolo, Michele, St George-Hyslop, Peter
פורמט: Artigo
שפה:Inglês
יצא לאור: Cell Press 2018
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927716/
https://ncbi.nlm.nih.gov/pubmed/29677515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.056
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