The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration

Many RNA binding proteins, including FUS, contain moderately repetitive, low complexity, intrinsically disordered domains. These sequence motifs have recently been found to underpin reversible liquid: liquid phase separation and gelation of these proteins, permitting them to reversibly transition fr...

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Detalhes bibliográficos
Publicado no:Brain Res
Main Authors: St George-Hyslop, Peter, Lin, Julie Qiaojin, Miyashita, Akinori, Phillips, Emma C., Qamar, Seema, Randle, Suzanne J., Wang, GuoZhen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier/North-Holland Biomedical Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018615/
https://ncbi.nlm.nih.gov/pubmed/29723523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2018.04.036
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