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Differential Contributions of Caenorhabditis elegans Histone Deacetylases to Huntingtin Polyglutamine Toxicity

Expansion of a polyglutamine tract in the huntingtin protein causes neuronal degeneration and death in Huntington's disease patients, but the molecular mechanisms underlying polyglutamine-mediated cell death remain unclear. Previous studies suggest that expanded polyglutamine tracts alter trans...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bates, Emily A., Victor, Martin, Jones, Adriana K., Shi, Yang, Hart, Anne C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675170/
https://ncbi.nlm.nih.gov/pubmed/16525063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3344-05.2006
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