Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans

Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pharmacol Res
Egile Nagusiak: Gómez-Escribano, AP, Bono-Yagüe, J, García-Gimeno, MA, Sequedo, MD, Hervás, D, Fornés-Ferrer, V, Torres-Sánchez, SC, Millán, JM, Sanz, P, Vázquez-Manrique, RP
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755709/
https://ncbi.nlm.nih.gov/pubmed/32739430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2020.105105
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