Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans

Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions...

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Pubblicato in:Pharmacol Res
Autori principali: Gómez-Escribano, AP, Bono-Yagüe, J, García-Gimeno, MA, Sequedo, MD, Hervás, D, Fornés-Ferrer, V, Torres-Sánchez, SC, Millán, JM, Sanz, P, Vázquez-Manrique, RP
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755709/
https://ncbi.nlm.nih.gov/pubmed/32739430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2020.105105
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