Structural Insights into Phospholipase C-β Function

von Lyon, Angeline M., Tesmer, John J. G.
Veröffentlicht 2013

Structure and Regulation of Phospholipase Cβ and ε at the Membrane

von Muralidharan, Kaushik, Van Camp, Michelle M., Lyon, Angeline M.
Veröffentlicht in Chem Phys Lipids (2021)

Strike a Pose: Gα(q) Complexes at the Membrane

von Lyon, Angeline M., Taylor, Veronica G., Tesmer, John J. G.
Veröffentlicht 2013

Bruno Protein Contains an Expanded RNA Recognition Motif

von Lyon, Angeline M., Reveal, Brad S., Macdonald, Paul M., Hoffman, David W.
Veröffentlicht in Biochemistry (2009)

Gα(q) and the Phospholipase Cβ3 X–Y Linker Regulate Adsorption and Activity on Compressed Lipid Monolayers

von Hudson, Brianna N., Jessup, Rachel E., Prahalad, Keshav K., Lyon, Angeline M.
Veröffentlicht in Biochemistry (2019)

Molecular Mechanisms of PLCβ3 Autoinhibition

von Lyon, Angeline M., Begley, Jessica A., Manett, Taylor D., Tesmer, John J. G.
Veröffentlicht in Structure (2014)

G protein βγ subunits directly interact with and activate phospholipase Cϵ

von Madukwe, Jerry C., Garland-Kuntz, Elisabeth E., Lyon, Angeline M., Smrcka, Alan V.
Veröffentlicht in J Biol Chem (2018)

Full-Length Gα(q)–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain

von Lyon, Angeline M., Dutta, Somnath, Boguth, Cassandra A., Skiniotis, Georgios, Tesmer, John J. G.
Veröffentlicht 2013

Quantifying acute fuel and respiration dependent pH homeostasis in live cells using the mCherryTYG mutant as a fluorescence lifetime sensor.

von Haynes, Emily P., Rajendran, Megha, Henning, Chace K., Mishra, Abhipri, Lyon, Angeline M., Tantama, Mathew
Veröffentlicht in Anal Chem (2019)

Intramolecular Electrostatic Interactions Contribute to Phospholipase Cβ3 Autoinhibition

von Esquina, Candi M., Garland-Kuntz, Elisabeth E., Goldfarb, Daniel, McDonald, Emily K., Hudson, Brianna N., Lyon, Angeline M.
Veröffentlicht in Cell Signal (2019)

Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A

von Sieng, Monita, Selvia, Arielle F., Garland-Kuntz, Elisabeth E., Hopkins, Jesse B., Fisher, Isaac J., Marti, Andrea T., Lyon, Angeline M.
Veröffentlicht in J Biol Chem (2021)

High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members

von Sieng, Monita, Hayes, Michael P., O'Brien, Joseph B., Andrew Fowler, C., Houtman, Jon C., Roman, David L., Lyon, Angeline M.
Veröffentlicht in J Biol Chem (2019)

Direct observation of conformational dynamics of the PH domain in phospholipases Cϵ and β may contribute to subfamily-specific roles in regulation

von Garland-Kuntz, Elisabeth E., Vago, Frank S., Sieng, Monita, Van Camp, Michelle, Chakravarthy, Srinivas, Blaine, Arryn, Corpstein, Clairissa, Jiang, Wen, Lyon, Angeline M.
Veröffentlicht in J Biol Chem (2018)

An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gα(q) Activation

von Lyon, Angeline M., Tesmer, Valerie M., Dhamsania, Vishan D., Thal, David M., Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C., Northup, John K., Tesmer, John J. G.
Veröffentlicht 2011

Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements

von Rugema, Ngango Y., Garland-Kuntz, Elisabeth E., Sieng, Monita, Muralidharan, Kaushik, Van Camp, Michelle M., O’Neill, Hannah, Mbongo, William, Selvia, Arielle F., Marti, Andrea T., Everly, Amanda, McKenzie, Emmanda, Lyon, Angeline M.
Veröffentlicht in Commun Biol (2020)