An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gα(q) Activation

Phospholipase C-β (PLCβ) is a key regulator of intracellular calcium levels whose activity is controlled by heptahelical receptors that couple to G(q). We have determined atomic structures of two invertebrate homologs of PLCβ (PLC21) from cephalopod retina and identified a helix from the C-terminal...

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Main Authors: Lyon, Angeline M., Tesmer, Valerie M., Dhamsania, Vishan D., Thal, David M., Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C., Northup, John K., Tesmer, John J. G.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168981/
https://ncbi.nlm.nih.gov/pubmed/21822282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2095
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