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Full-Length Gα(q)–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain
Phospholipase C-β (PLCβ) is directly activated by Gα(q), but the molecular basis for how its distal C-terminal domain (CTD) contributes to maximal activity is poorly understood. Herein we present both the crystal structure and cryo-EM 3D reconstructions of human full-length PLCβ3 in complex with mur...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594540/ https://ncbi.nlm.nih.gov/pubmed/23377541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2497 |
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