Full-Length Gα(q)–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain

Phospholipase C-β (PLCβ) is directly activated by Gα(q), but the molecular basis for how its distal C-terminal domain (CTD) contributes to maximal activity is poorly understood. Herein we present both the crystal structure and cryo-EM 3D reconstructions of human full-length PLCβ3 in complex with mur...

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Detaylı Bibliyografya
Asıl Yazarlar: Lyon, Angeline M., Dutta, Somnath, Boguth, Cassandra A., Skiniotis, Georgios, Tesmer, John J. G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594540/
https://ncbi.nlm.nih.gov/pubmed/23377541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2497
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