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G protein βγ subunits directly interact with and activate phospholipase Cϵ
Phospholipase C (PLC) enzymes hydrolyze membrane phosphatidylinositol 4,5 bisphosphate (PIP(2)) and regulate Ca(2+) and protein kinase signaling in virtually all mammalian cell types. Chronic activation of the PLCϵ isoform downstream of G protein–coupled receptors (GPCRs) contributes to the developm...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5925795/ https://ncbi.nlm.nih.gov/pubmed/29535186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002354 |
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