G protein βγ subunits directly interact with and activate phospholipase Cϵ

Phospholipase C (PLC) enzymes hydrolyze membrane phosphatidylinositol 4,5 bisphosphate (PIP(2)) and regulate Ca(2+) and protein kinase signaling in virtually all mammalian cell types. Chronic activation of the PLCϵ isoform downstream of G protein–coupled receptors (GPCRs) contributes to the developm...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Madukwe, Jerry C., Garland-Kuntz, Elisabeth E., Lyon, Angeline M., Smrcka, Alan V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925795/
https://ncbi.nlm.nih.gov/pubmed/29535186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002354
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