Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

Por Smrcka, Alan V.
Publicado em 2013

Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes

Por Smrcka, Alan V.
Publicado no J Cardiovasc Pharmacol (2015)

Understanding Molecular Recognition by G protein βγ Subunits on the Path to Pharmacological Targeting

Por Lin, Yuan, Smrcka, Alan V.
Publicado em 2011

Activated heterotrimeric G protein α(i) subunits inhibit Rap-dependent cell adhesion and promote cell migration

Por To, Jesi Y., Smrcka, Alan V.
Publicado no J Biol Chem (2018)

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

Por Smrcka, Alan V., Fisher, Isaac
Publicado no Cell Mol Life Sci (2019)

HPLC Separation and Indirect Ultraviolet Detection of Phosphorylated Sugars

Por Smrcka, Alan V., Jensen, Richard G.
Publicado em 1988

Phenotypical Temperature Adaptation of Protein Turnover in Desert Annuals

Por Smrcka, Alan V., Szarek, Stan R.
Publicado em 1986

Discovery of Ligands for βγ Subunits from Phage-Displayed Peptide Libraries

Por Smrcka, Alan V., Scott, Jamie K.
Publicado em 2002

Targeting G protein-coupled receptor signalling by blocking G proteins

Por Campbell, Adrian P., Smrcka, Alan V.
Publicado no Nat Rev Drug Discov (2018)

WDR26 Functions as a Scaffolding Protein to Promote Gβγ-mediated Phospholipase C β2 (PLCβ2) Activation in Leukocytes

Por Sun, Zhizeng, Smrcka, Alan V., Chen, Songhai
Publicado em 2013

Conformational flexibility and binding interactions of the G protein βγ heterodimer

Por Park, Min-Sun, Smrcka, Alan V., Stern, Harry
Publicado em 2011

A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis

Por Surve, Chinmay R., Lehmann, David, Smrcka, Alan V.
Publicado em 2014

Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.

Por Kelley, Grant G, Reks, Sarah E, Smrcka, Alan V
Publicado em 2004

MECHANISTIC PATHWAYS AND BIOLOGICAL ROLES FOR RECEPTOR-INDEPENDENT ACTIVATORS OF G-PROTEIN SIGNALING

Por Blumer, Joe B., Smrcka, Alan V., Lanier, S.M.
Publicado em 2006

A Novel Gβγ-Subunit Inhibitor Selectively Modulates μ-Opioid-Dependent Antinociception and Attenuates Acute Morphine-Induced Antinociceptive Tolerance and Dependence

Por Mathews, Jennifer L., Smrcka, Alan V., Bidlack, Jean M.
Publicado em 2008

G Protein βγ Subunits as Targets for Small Molecule Therapeutic Development

Por Smrcka, Alan V., Lehmann, David M., Dessal, Axel L.
Publicado em 2008

Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits

Por Kamal, Fadia A., Smrcka, Alan V., Blaxall, Burns C.
Publicado em 2011

Direct-reversible binding of small molecules to G protein βγ subunits

Por Seneviratne, AMPB, Burroughs, Michael, Giralt, Ernest, Smrcka, Alan V.
Publicado em 2011

Role of phospholipase Cε in physiological phosphoinositide signaling networks

Por Smrcka, Alan V., Brown, Joan Heller, Holz, George G.
Publicado em 2012

Rational Design of a Selective Covalent Modifier of G Protein βγ Subunits

Por Dessal, Axel L., Prades, Roger, Giralt, Ernest, Smrcka, Alan V.
Publicado em 2011