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WDR26 Functions as a Scaffolding Protein to Promote Gβγ-mediated Phospholipase C β2 (PLCβ2) Activation in Leukocytes

We have recently identified WDR26 as a novel WD40 repeat protein that binds Gβγ and promotes Gβγ signaling during leukocyte migration. Here, we have determined the mechanism by which WDR26 enhances Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. We show that WDR26 not only directly...

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Библиографические подробности
Главные авторы: Sun, Zhizeng, Smrcka, Alan V., Chen, Songhai
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675605/
https://ncbi.nlm.nih.gov/pubmed/23625927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.462564
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