Phospholipase Cϵ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes

To define a role for phospholipase Cϵ (PLCϵ) signaling in cardiac myocyte hypertrophic growth, PLCϵ protein was depleted from neonatal rat ventricular myocytes (NRVMs) using siRNA. NRVMs with PLCϵ depletion were stimulated with endothelin (ET-1), norepinephrine, insulin-like growth factor-1 (IGF-1),...

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Detalhes bibliográficos
Main Authors: Zhang, Lianghui, Malik, Sundeep, Kelley, Grant G., Kapiloff, Michael S., Smrcka, Alan V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123069/
https://ncbi.nlm.nih.gov/pubmed/21550986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.231993
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