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Compartmentalized Cyclic Nucleotides Have Opposing Effects on Regulation of Hypertrophic Phospholipase Cε Signaling in Cardiac Myocytes

In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development of cardiac hypertrophy. Here we show that β-adrenergi...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Nash, Craig A., Brown, Loren M., Malik, Sundeep, Cheng, Xiaodong, Smrcka, Alan V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373484/
https://ncbi.nlm.nih.gov/pubmed/29885334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.06.002
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