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Epac and Phospholipase Cε Regulate Ca(2+) Release in the Heart by Activation of Protein Kinase Cε and Calcium-Calmodulin Kinase II

Recently, we identified a novel signaling pathway involving Epac, Rap, and phospholipase C (PLC)ε that plays a critical role in maximal β-adrenergic receptor (βAR) stimulation of Ca(2+)-induced Ca(2+) release (CICR) in cardiac myocytes. Here we demonstrate that PLCε phosphatidylinositol 4,5-bisphosp...

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Detaylı Bibliyografya
Asıl Yazarlar: Oestreich, Emily A., Malik, Sundeep, Goonasekera, Sanjeewa A., Blaxall, Burns C., Kelley, Grant G., Dirksen, Robert T., Smrcka, Alan V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615515/
https://ncbi.nlm.nih.gov/pubmed/18957419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806994200
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