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Epac and Phospholipase Cε Regulate Ca(2+) Release in the Heart by Activation of Protein Kinase Cε and Calcium-Calmodulin Kinase II
Recently, we identified a novel signaling pathway involving Epac, Rap, and phospholipase C (PLC)ε that plays a critical role in maximal β-adrenergic receptor (βAR) stimulation of Ca(2+)-induced Ca(2+) release (CICR) in cardiac myocytes. Here we demonstrate that PLCε phosphatidylinositol 4,5-bisphosp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2615515/ https://ncbi.nlm.nih.gov/pubmed/18957419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806994200 |
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