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Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site
Mammalian phospholipase C-β (PLC-β) isoforms are stimulated by heterotrimeric G protein subunits and members of the Rho GTPase family of small G proteins. Although recent structural studies showed how Gα(q) and Rac1 bind PLC-β, there is a lack of consensus regarding the Gβγ binding site in PLC-β. Us...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900283/ https://ncbi.nlm.nih.gov/pubmed/27002154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.723940 |
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