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Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site

Mammalian phospholipase C-β (PLC-β) isoforms are stimulated by heterotrimeric G protein subunits and members of the Rho GTPase family of small G proteins. Although recent structural studies showed how Gα(q) and Rac1 bind PLC-β, there is a lack of consensus regarding the Gβγ binding site in PLC-β. Us...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Kadamur, Ganesh, Ross, Elliott M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900283/
https://ncbi.nlm.nih.gov/pubmed/27002154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.723940
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