Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

Pleckstrin homology (PH) domains have been identified only in eukaryotic proteins to date. We have determined crystal structures for three members of an uncharacterized protein family (Pfam PF08000), which provide compelling evidence for the existence of PH-like domains in bacteria (PHb). The first...

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Main Authors: Xu, Qingping, Bateman, Alex, Finn, Robert D., Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L., Bakolitsa, Constantina, Carlton, Dennis, Chen, Connie, Chiu, Hsiu-Ju, Chiu, Michelle, Clayton, Thomas, Das, Debanu, Deller, Marc C., Duan, Lian, Ellrott, Kyle, Ernst, Dustin, Farr, Carol L., Feuerhelm, Julie, Grant, Joanna C., Grzechnik, Anna, Han, Gye Won, Jaroszewski, Lukasz, Jin, Kevin K., Klock, Heath E., Knuth, Mark W., Kozbial, Piotr, Krishna, S. Sri, Kumar, Abhinav, Marciano, David, McMullan, Daniel, Miller, Mitchell D., Morse, Andrew T., Nigoghossian, Edward, Nopakun, Amanda, Okach, Linda, Puckett, Christina, Reyes, Ron, Rife, Christopher L., Sefcovic, Natasha, Tien, Henry J., Trame, Christine B., van den Bedem, Henry, Weekes, Dana, Wooten, Tiffany, Hodgson, Keith O., Wooley, John, Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Wilson, Ian A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817789/
https://ncbi.nlm.nih.gov/pubmed/19913036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.006
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